The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My MIL Came to My Work Demanding I Pay for Expensive Caviar — the Lesson I Taught Her Had Everyone Applauding
My mother-in-law and I never saw eye to eye, and she always tried to get under my skin. But when she pulled a stunt at my workplace, I had enough and decided to teach her a valuable lesson then and there, to the praise of my colleagues and manager.
Yesterday, I was about halfway through my shift at an upscale grocery store where I work part-time when I saw her: Denise, my mother-in-law (MIL). She was strolling through the automatic doors like she was walking into her kingdom. Little did I know that her presence would cause a confrontation where I was forced to stand up for myself.
A cashier in a grocery store | Source: Midjourney
The store’s faint background music did nothing to dull the sound of her heels clacking on the polished floor as she made her grand entrance, dripping with expensive jewelry. Denise had that air about her like everyone should stop what they were doing and admire her presence.
And to be honest, she kind of expected it.
She was in her usual “look-at-me” outfit: a tailored designer coat, big sunglasses despite it being perfectly lit indoors, and a diamond necklace that probably cost more than I made in a year.
A well-dressed woman in a store | Source: Midjourney
When she strutted straight toward my register, a smirk already forming on her lips, my stomach did a little flip. What on earth was she doing here?
Denise had never come to my job before, and at that very moment, part of me wished it could’ve stayed that way forever. The woman had a way of making me feel two inches tall as if her disapproving looks and passive-aggressive comments weren’t enough of a daily reminder that I wasn’t “good enough” for her precious son, Jack.
A man posing alone | Source: Freepik
We’ve been married for five years, and still, my MIL found ways to remind me that I didn’t measure up to her standards. My husband didn’t help much and always appeared to take her side to avoid further drama, saying things like, “That’s just how Mom is.”
His unwillingness to have my back drove me insane! But I love him and believed my MIL would eventually get tired. For years, I put up with her antics and continued biting my tongue… until yesterday. Yesterday was the last time Denise messed with me because I taught her a lesson she’d never forget.
Here’s how it happened…
A cashier in a store | Source: Midjourney
She stopped in front of my register and gave me that fake smile that sent chills down my spine. In her arms were two cans of caviar, the specialty, high-end, top-of-the-line kind that cost more than my rent.
I glanced at the price tags. Yep, it was as bad as I thought: hundreds of dollars for two tiny tins.
“Sweetheart,” Denise said in that sickly sweet tone she always used when she wanted something. She dropped the cans down with a soft thud on the counter and glanced over her shoulder, probably making sure we had an audience.
“I need you to take care of this.”
An arrogant woman placing caviar on the counter | Source: Midjourney
Confused, I blinked, trying to process what she was asking.
“Sure,” I replied, reaching to scan the cans for her, but she stopped me to clarify.
“No, silly, I need you to TAKE CARE OF IT, darling,” she replied, looking annoyed but thrilled to be putting me on the spot.
“Take care of it?” I repeated, unsure if I’d heard her right or understood what she really wanted.
Denise tilted her head and gave me a pitying look like I was a child who couldn’t understand basic math.
“PAY for the caviar, my dear. You’ve always been so slow,” she said as if she were explaining the most obvious thing in the world.
An unhappy woman with her arms crossed | Source: Midjourney
“See, I’m hosting a little dinner party tonight, and my friends are expecting ONLY the best. I’m sure Jack wouldn’t mind if you helped out. After all, it’s what family does. And I’m certain you wouldn’t want me to disappoint my guests, would you?”
I stared at her, my hands frozen on the register. Stunned is an understatement for how I felt at that moment. I wanted to laugh, but the words were caught in my throat.
“Denise, this is hundreds of dollars’ worth of caviar,” I said, my voice low, trying to keep my composure. “I can’t—”
But she cut me off with a dismissive wave of her hand.
A woman waving her hand dismissively | Source: Midjourney
“Oh, don’t be so dramatic,” she scoffed. “My Jack will cover it. You’re his wife, and it’s your job to help with things like this.”
Now, I had put up with a lot from Denise over the years, but this? This was new. She wanted me to shell out hundreds of dollars, on the spot, for some caviar that she absolutely didn’t need, just so she could impress her fancy friends!
My co-workers were watching, probably wondering what was happening. I could feel their eyes on me, the customers in line shifting awkwardly as they pretended not to eavesdrop.
Shocked customers staring in one direction | Source: Midjourney
“Denise,” I said, trying to keep my voice steady, “I’m not paying for your caviar.”
Her smile faltered, but only for a second. She quickly recovered, brushing off my refusal like a minor inconvenience.
“Oh, come on, honey,” she said, her voice dripping with false kindness. “Don’t be selfish. You know how important this is to me. My friends expect the best.” She leaned in closer and whispered, “If you don’t help me out here, I’ll make sure Jack knows exactly how uncooperative you’re being.”
A woman addressing someone | Source: Midjourney
That was it…
Something inside me snapped. I wasn’t about to let this woman blackmail me in front of a crowd, in my own workplace no less! I squared my shoulders and gave her a sweet but tight-lipped smile, pretending to go along with her demands.
“You know what, Denise?” I said, my voice a little louder now. “You’re absolutely right. I’ll take care of it.”
Her eyes lit up with satisfaction, convinced she had won. “I knew you’d see reason,” she said, already preparing to bask in her victory.
A woman smiling in a store | Source: Midjourney
I grabbed the cans of caviar and scanned them, feeling the weight of every dollar as it added up on the register. My heart was pounding, but I knew exactly what I was going to do. After I bagged the caviar when my MIL wasn’t looking, I leaned forward and pressed the microphone button at my register.
My voice rang out loud and clear over the speakers as I gave Denise a taste of her own medicine, but amplified…
A woman holding a megaphone | Source: Midjourney
“Attention, shoppers,” I said, trying to keep the glee out of my voice.
“I’d like to introduce you all to a very special guest today, my mother-in-law, Denise! She’s here to buy two cans of our finest caviar, and she’s asked me, her cashier daughter-in-law, to pay for them. Let’s give her a round of applause for being such a generous family member!”
For a split second, the store was dead silent. Then, someone in the back started clapping, slowly at first, but then others joined in. Soon enough, the whole store was clapping and cheering!
Customers clapping in a grocery store | Source: Midjourney
My co-workers were grinning from ear to ear, and even the customers in line were chuckling and clapping along!
Denise’s face turned a shade of red I’d never seen before!
“What the hell are YOU doing?” she hissed under her breath, glaring at me like I’d just committed a crime.
I kept smiling, pretending to be oblivious.
“Oh, I just thought everyone should know how generous you are, Denise. Isn’t that what you wanted?”
A smug cashier | Source: Midjourney
She snatched the bag from the counter, her lips pressed into a thin line. Without another word, she stormed out of the store, her heels clicking furiously against the tile floor as the applause continued!
It didn’t stop until she was well out the door, and by then, I was practically glowing from the satisfaction of it all!
After she left, my co-worker Rachel sidled up next to me, barely able to contain her laughter.
“That,” she whispered, “was the most LEGENDARY thing I’ve ever seen!”
A shocked cashier | Source: Midjourney
The store manager, who’d been watching the whole thing from the back, gave me a wink as he passed by. “Remind me to never get on your bad side,” he said, grinning.
I couldn’t stop smiling as I finished my shift. It wasn’t just the applause or the fact that I’d finally stood up to Denise in such a public way. It was knowing that, for once, I’d outplayed her.
It wasn’t until later that night, when I got home, that the full impact of what happened hit me. Jack was sitting on the couch, his phone in hand, looking confused and impressed at the same time.
A confused man looking at his phone | Source: Freepik
“What the hell happened with my mom today?” he asked, not quite able to hide the hint of a smile.
I sat down next to him and told him everything. I braced myself, expecting him to be mad or at least a little annoyed. But instead, he just shook his head, fighting back a laugh.
“You know,” he said, “I think she might leave us alone for a while.”
And guess what? He was right. My MIL hasn’t called, texted, or shown up since!
A happy couple | Source: Midjourney
Denise sadly isn’t the only troublesome MIL out there. Jane moved in with her son and his wife, pretending to have issues with her home, only to find out she wanted to monitor the couple and ensure they give her grandchildren. Her daughter-in-law was having none of it and retaliated the best way she knew how.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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