The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
A woman converts a Boeing 747 into a fully functional home.
Buses, tiny houses, and shipping containers have all become popular building materials for one-of-a-kind homes.
These affordable substitutions for conventional housing provide the same level of comfort and a variety of customization options.
Jo Ann Ussery, on the other hand, designed her own unique home before it became popular.
She bought an old Boeing 727 and turned it into a lovely house.
Wonderful housing.
When Ussery’s home in Benoit, Mississippi, was destroyed in 1993, her adventure officially began.
She and her two kids needed a place to live because her husband had unexpectedly passed away, but they weren’t wealthy.
She had believed that purchasing a trailer would make all of her problems go away, but she soon realized she couldn’t afford a house big enough to accommodate her enormous family.
Ussery’s brother-in-law Bob, who works as an air traffic controller, suggested they try living aboard a plane.
Ussery was drawn to the idea and visited a Boeing 727 that had been disassembled for its parts.
Despite the piece’s $2,000 price tag (including shipping), she fell in love at first sight.
Ussery nicknamed her private Boeing 727 “Little Trump” after learning that Donald Trump also owned a private Boeing 727.
She started her expensive and time-consuming home improvements right away.
Less than $30,000 (or about $60,000 in modern currency) went toward the renovation.
While she worked on the inside, she needed to make sure it stayed in its current position.
Ussery made use of the lake that was already present on her property by bringing the plane down with its nose over the water. To achieve this specific goal, a sizable amount of concrete was used to secure the tail. The interior, which was roughly 1,500 square feet, was immediately demolished by her.
The aircraft measures 138 feet in length and has 76 windows.
Although the aircraft’s windows weren’t functional, as is typical of commercial aircraft, she wasn’t bothered by this because the air conditioning was working.
She upgraded the insulation and put in new flooring. What specific components of the original 727 were kept?
It is a brilliant idea to only have one airplane bathroom and overhead bins for your belongings.
The interior design.
Ussery was able to concentrate on the finer details and improved comforts once the significant changes were finished.
The remodeled jet had three bedrooms, a living room, a kitchen, and even a laundry room.
The washer and dryer were there, but it also had a phone and an oven.
Without a doubt, Ussery’s work on the cockpit’s view of the lake was the most significant improvement.
It was transformed into a royal master bathroom with a soaking tub by her.
She designed the room’s layout to give everyone who was in it the sensation of floating.
The renovation was completed entirely by Ussery, which is especially noteworthy.
Before deciding to make her converted plane into a public museum, she lived there from 1995 to 1999.
Sadly, after being transported a short distance, it fell off the carriage and collapsed.
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