The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Tom Jones opens up about his marriage and love life after wife’s passing
After Linda’s death, Tom cancelled all his concerts and released a short statement:
Wife’s passing
“Surrounded by her husband and loved ones, she passed away peacefully,” the Sir Tom’s website wrote.
But last year, Sir Tom opened up on her tragic death. In an interview with This Morning, the Welshman said he would “never love again”.
His wife’s passing really crushed him and he struggled to perform on stage long after Linda was gone.
“When my wife passed away, I didn’t think I could sing,” Sir Tom explained. “When you’re emotional, you can’t sing, your voice closes up.
“There are certain songs I wouldn’t do. But you have to try and get things in the right perspective. Feeling emotional; use it to your advantage and put it into the song.
Now lives in London
“It took me a while,” he continued. “Took me a few months to try and see if I could sing. I got some of my musicians around and tried a few songs. But it was very emotional.”
Linda’s passing also had other consequences – Jones decided to sell their big mansion in Los Angeles, along with all their furniture, in order to move back to the UK.
Today he lives in a flat in London – that was Linda’s wish. His late wife had been homesick and wanted to move back to her roots, but cancer took her life before it was possible.
“She always said she wanted to come back and then she could not do it, so then she told me to do it in the last week she was alive,” said Sir Tom, who was married to Linda for 59 years.
There is no doubt that Jones still mourns Linda, whom he married at the age of 16. The couple met when Linda was 15.
Speaking to Radio 2, Sir Tom described the moment he first saw his wife-to-be:
“I remember her playing marbles and I thought, ‘My God, what great legs she’s got’. She was the best-looking girl around there and we got together. It was magic”, the singer said.
Linda and Sir Tom tied the knot as teenagers, just a month before their son, Mark, was born.
But their marriage would be rife with scandals and infidelity. For more than 50 years, Tom cheated on his wife.
om, who assumed the role of sex symbol, has previously admitted that he slept with 250 women a year at the peak of his career.
“From the very beginning, he was not exactly Mr Faithful,” biographer Sean Smith told Daily Mail in 2015.
It’s unclear how much Linda knew about her husband’s shady side, but it is clear that she suspected something wasn’t right. According to Sir Tom, the couple had a “don’t ask” policy when he was on tour.
”Linda lived a quiet life and rarely left the couple’s villa in Bel Air. During her single marriage to Tom, she has also had alcohol problems,” Robin Eggar, who wrote the official biography of Tom Jones, told the Daily Mail.
After 2003, the wife stopped accompanying her husband on his tours and remained mostly at home in the couple’s Bel Air mansion.
By then, she had already endured several scandals that must have tarnished their relationship.
In 1987, Tom Jones had a three-day fling with the 24-year-old Katherine Berkery, during tour in the US. According to reports, Katherine had no idea he was married and Tom refused to return her phone calls when she discovered she was pregnant with his child.
Nine months later, Jonathan Berkery was born in New York, in June 1988. Sir Tom denied he was Jon’s dad and refused to admit that it was his child.
Leave a Reply