The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Fans worried Miley Cyrus in “in danger” after spotting bodyguard’s hidden move at Grammy Awards
It was a big night for singer Miley Cyrus last night as she took home her first ever Grammy Award.
However, this morning it wasn’t just Miley’s success that was being talked about online, but also the worrying idea that she may have been in danger.
Why? Well, some eagle-eyed speculators online have suggested that they saw “odd behavior” from her bodyguard which might imply that he was anticipating a threat of some kind.
Now, we feel it necessary at this point to make it clear that there is no evidence that Cyrus was in any danger, beyond what people are claiming to have seen in a video doing the rounds online.
Nevertheless, said clip has garnered so much attention that it just won’t do to ignore it. So, here goes.
The video in question comes from the red carpet at the 2024 Grammy Awards, which took place last night (February 4) and saw a number of musicians – like, a lot of them – win awards for their work over the past year.
The evening saw Taylor Swift win her fourth Album of the Year award, and featured a surprise appearance from Celine Dion as a presenter. Miley Cyrus also won her first ever Grammy, but it’s arguably a video trending on X that has become the most talked about point of the night where the 31-year-old is concerned.
As mentioned, footage of Cyrus on the event’s red carpet has gone viral. The clip, which shows the Wrecking Ball singer walking beside her bodyguard, who is carrying an umbrella, is only eight seconds long, but has already wracked up a mind-boggling 32 million views.
At first glance there isn’t much of anything to spot in the video – anything out of the ordinary, in any case – but take one look at what people are saying on X and you’ll be brought up to speed.
“Fake arm holding umbrella. So arm is under coat presumably with a weapon. Completely unnecessary at the Grammy Awards. This bodyguard is a clown. But in serious environments the fake arm is a common tactic,” one person commented.
“Auto firearm dressed as an umbrella?” another speculated.
“Pay close attention to Miley Cyrus’s bodyguard in this video at the Grammys all is not as it seems,” a third wrote.
A fourth added: “Did you catch the mysterious moves of Miley Cyrus‘s bodyguard at the Grammys There’s more to the story than meets the eye!“
Naturally there were others who took a less suspicious approach to the whole thing.
“It’s an umbrella weapon to rain lol! Not a gun,” one X user wrote.
Another added: “Miley Cyrus’s bodyguard is either carrying a gun disguised as an umbrella or is wearing a fake arm to disguise his real arm, again for security reasons. Bla, bla, bla. People are going nuts. It was raining. It’s an umbrella.“
“Tha narrative of a fake arm sounds good but let’s be realistic, it’s Miley Cyrus at the Grammies. This isn’t some world leader and I’m literally staring at his live hand holding an umbrella. It’s his juts him walking like he’s on a runway,” a third said.
Miley Cyrus – Flowers l Live Performance at Grammy Awards 2024
What do you think? Have you had a look at the footage? Let us know
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