The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Dаd & Dаughtеr Rесrеаtе Нigh Sсhооl Grаd Рhоtо Аftеr 18 Yеаrs – Реорlе Lооk Сlоsеr Аnd Sроt А Dеtаil Тhеy Саn’t Lеt Gо
As a parent, seeing your child graduate from high school or college is one of the most memorable events in your life.
People who have been through it will remember the pride and unbridled joy that come from seeing your not-so-little one finish a part of their life they worked so hard to complete.
Dennis Roach, a dad from Texas, must have felt ten times better in 2018 because his daughter’s high school graduation gave him the chance to take a picture from 2000 all over again, and the result made people all over the world smile…
Dennis finished high school in 2000, and he was lucky to have his toddler daughter Tori with him for the party.
At the time, they posed for a picture, and Dennis kissed his little girl. It was the right way to remember his big day.
In 2018, Tori Roach was the one who marked the occasion of her high school graduation.
Dennis was, of course, there to celebrate the occasion, and he and the other person had the great idea to take a new picture of the two of them from eighteen years ago.
In the new story, Tori lay in her dad’s arms and got a kiss on the face again.
People on Twitter loved the pictures she posted of the pictures from 2000 and 2018. No one could have predicted how well it would be received.
“18 years later,” Tori wrote under her picture. It quickly went global, getting 57,000 reposts and almost 150,000 likеs.
In the comments section, many people were happy to see the picture.
“Ugh this is just the sweetest,” one person wrote.
Another added: “One of the best pictures I have seen … I wish you and your family the best of luck.”
“Wow lovely…” a third said.
But the feature that a lot of people saw and couldn’t help but comment on was probably the most interesting thing about the two pictures.
One thing that stood out was that Tori’s dad, Dennis, didn’t look likе he had aged at all between the two pictures.
“How old is your father,” mused one person. “He looks ageless.”
“I think you froze your father until you grow up,” another joked.
“Damn did you dad age any?” a third quipped.
Tori couldn’t believe how many people were interested in her post.
She later had to explain that her dad, who was 37 years old when she graduated from high school, wasn’t single.
She also talked to People about Dennis’s pride.
“I woke up and I had a ton of notifications. People had started sharing and liking and commenting all over again. My dad was really proud. We’re from a small town, so nothing likе this really ever happens. And he was likе, ‘That’s so cool!’”
She added, “It brought me and my dad closer in a way because we could shаrе that moment, and I feel that not many other people get to experience that.”
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