The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
70s’ heartthrob Christopher Atkins disappeared from the spotlight – see him now at 63
The actor who once stole hearts in The Blue Lagoon has resurfaced, looking very different from his teenage days – with silver hair and lines etched into his face, his transformation reflects a life fully
lived.
Away from Hollywood’s limelight, he faced struggles that nearly broke him, but today, he’s embraced a quieter life.
Let’s look at the twists and turns of his journey, from battling alcoholism to bankruptcy, and where he stands now…
Christopher Atkins, the former Blue Lagoon star, skyrocketed to fame over four decades ago, largely due to his role in the iconic 1980 film. Although acting was not his initial dream, fate had other plans.
Born in New York, Atkins grew up aspiring to become a professional baseball player, but a knee injury ended his athletic ambitions. Instead of heading to the baseball field, he found himself teaching sailing and trying his hand at modeling. A fateful audition led to his breakthrough as Richard in The Blue Lagoon, a role that would change his life forever.
Atkins was chosen from among 4,000 hopefuls for the part, a testament to his undeniable on-screen charisma, Now to Love detailed. The film, co-starring Brooke Shields, told the story of two teenagers stranded on a tropical island and quickly became a box-office sensation.
One of the first mainstream movies to feature male nudity, it was an intimidating experience for the young actor, but his performance captured audiences worldwide.
Following his success in The Blue Lagoon, Atkins went on to star in The Pirate Movie, where he met Australian model Lyn Barron.
Reminiscing on their whirlwind romance, he shared: “It was love at first sight, and six months later we were married. We went on to have two kids, Grant and Brittany.” However, the glamorous Hollywood life came with a darker side.
As Atkins’ career progressed, the pressures of fame began to weigh heavily. Constant travel, extravagant parties, and high expectations led him down a dangerous path of alcoholism.
Although the family had settled in Los Angeles, their seemingly perfect life unraveled when Atkins discovered that his former manager had embezzled nearly half a million dollars from him. The financial betrayal left the star nearly bankrupt, leading to an alcohol-fueled breakdown in 1986. Reflecting on that challenging period, he admitted to Lifestyle Magazine: “There is nothing worse than having your whole life pulled out from under you.
His turning point came after a heated argument with his wife, which prompted his parents to step in. Atkins entered rehab for 28 days to confront his addiction. After completing treatment, he emerged with a new perspective on life. “I came out of there realizing that I wanted to be a dad more than I wanted to be a drunk,” he said. Despite his efforts, his marriage couldn’t survive the strain of his struggles. “Sadly, the marriage didn’t last, but we remain genuinely great friends,” he added.
Atkins has now been sober for over 30 years, a milestone he takes pride in. He made a conscious effort to be a devoted father, focusing on his children, Grant and Brittany. Grant pursued baseball, chasing the dream his father once had, while Brittany ventured into acting, appearing in British children’s films, including one written by her father.
While Atkins continued to work in film and television, he longed for another major box office hit like The Blue Lagoon. “I consider myself an actor, that’s what I’ve done for 43 years… I still, to this day, dream of being in an ‘A’ movie again,” he revealed.
Outside of his career, Atkins remains hopeful about love. Having been married for 20 years and experienced other relationships, he still seeks a partner who shares his zest for life. “I want a woman, obviously no drama, I’m too old for that. A woman who loves to laugh, can be spontaneous…has to be open,” he shared, per Page Six.
Now a grandfather to three boys, Atkins finds immense joy in his role. “I take them snake hunting, we go camping, fishing, play ball, wrestle all the time, we have a blast. They’re so much fun,” he said.
Christopher Atkins’ transformation is a true testament to his resilience – what an inspiration to us all!
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