The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My Husband Wants a Divorce, but Demands That We Keep Living Together – And That’s Not Even the Craziest Part
I thought I knew my husband until he left me shocked and numb by throwing a major twist into our relationship. It was something I never anticipated but to add salt to the wound, he envisioned himself coming out the winner after breaking MY heart! I was having none of it!
Hey everyone, my name is Tanya, 34, and boy do I have a tale to tell! So basically, after being married for a decade, my husband, Alex, 35, suddenly surprised me when he told me he wanted a divorce! Okay, I am getting ahead of myself, I’m just so upset!
*Takes a deep breath*
Alright, let me tell you how this whole divorce thing came about and why my formerly loving husband now wanted to discard me.
Walking into our house that day, I was met with a sight that chilled me to the bone. There was some girl in the kitchen preparing a meal, and she was wearing my favorite pajamas—the ones with the quirky cats dancing across the fabric.
My husband is sprawled on the couch looking quite comfortable for someone who has a random woman in our home. I’m LIVID, all ready to make a scene, but then she turns around, and I just GASP… the woman is my sister, Clara, 38!
The air was thick with an unspoken tension that immediately put me on edge. “Clara, why are you here? And why in the world are you wearing my clothes?” My voice was a mix of bewilderment and rising irritation.
I was honestly shocked to see her there looking so comfortable in my home and thought maybe she got kicked out of her apartment or something and needed our assistance for a while.
Her response, delivered with a smirk that could curdle milk, sent shockwaves through me. “Oh, darling, I’m moving in. Didn’t Alex tell you?” Her casual dismissal of my feelings was a slap in the face, but the real blow came when Alex got up and wrapped his arms around her, their lips meeting in a kiss that was anything but brotherly!!!
My heart stopped, and for a moment, I couldn’t breathe. I was SHOCKED and felt dizzy! “You guys can’t be serious,” I gasped, my voice barely above a whisper. I felt a ringing in my ears as if an explosion had gone off as I put two and two together:
“My husband is dating MY SISTER!?”
“I haven’t been happy in our marriage for years, Tanya. And to be honest, I’d like to focus my attention on my career,” my cheating husband informed me. I figured my sister was in on his plan because she’d always been jealous of my life and relationship.
See Clara had always been our parents’ favorite and “angelic” child who could do no wrong, but as the years went by, they started seeing how she hid behind excuses and me to get out of taking any accountability for her life. “When are you getting a job Cla?” our parents would ask.
“You need to be more like your younger sister, find your way in life,” they’d say.
She resented that comparison because it meant she wasn’t their “good girl” anymore who just had to breathe to be celebrated. I only dated about two guys before meeting Alex, while Clara went through men like a toddler going through candy!
“Why do you always have to act perfect?” she’d taunt me when our parents came down hard on her. “I am not ‘perfect’ Clara, I am just trying my best. Have you ever considered doing that perhaps?” I’d challenge her. But I had no idea how far she’d go to be the shining star in the family, even if it meant taking something that wasn’t hers to take!
Andy’s confessions could fill a telenovela season as he spills about a decade-long affair, even trying to woo Jean right before her wedding. The audacity! It’s a rollercoaster of emotions, but his wife emerges not as a damsel in distress but a warrior, taking no prisoners and starting anew, with the measuring cup that uncovered the betrayal as a symbol of her newfound strength.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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