Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
✔ High fever
✔ Excessive night sweats
✔ Extreme fatigue
✔ Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
✔ Severe swelling in lymph nodes (especially in the neck)
✔ CT scan abnormalities indicating TB inflammation
✔ Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
🔴 Severe chills and fever
🔴 Uncontrollable night sweats
🔴 Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
✔ High-dose intravenous (IV) steroids for five days to calm the immune system
✔ A slow transition to oral steroids for three months
✔ Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
🔹 Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot.
🔹 Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications.
🔹 Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
⚠️ Myocarditis (heart muscle inflammation)
⚠️ Pericarditis (inflammation around the heart lining)
⚠️ Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
Our Granddaughter Demanded We Sell Our House to Help Her Boyfriend Start a Business – We Gave Her a Reality Check
When Mary and George become grandparents, they want nothing more than to spoil their granddaughter, Ellie. But as Ellie grows into herself, and is almost off to college—the couple have to teach her a lesson in understanding whom to trust with her heart, and their money.
The moment my daughter, Monica, was married, I realized that George and I had finally earned our time off. We were the parents of a married woman, who would eventually give us grandchildren.
A bride and groom | Source: Pexels
And until those grandchildren came into our lives—we were going to take advantage of the healthy years we had left.
A few years later, Monica and Eddie gave birth to our only granddaughter, Ellie.
A newborn baby girl | Source: Pexels
Time flew with George and I doting on her. She was our chance at redemption—for us to parent correctly.
“This little girl is everything,” George said when we came home from the hospital on the day Ellie was born.
“We’re going to give her all that we can, Mary, okay?” he said as we got into bed.
An unmade bed | Source: Pexels
I agreed. This was our opportunity to do everything correctly—and we had money now, so spoiling our granddaughter was something that we could do.
Fast forward to eighteen years later.
Now, Ellie is in high school, almost on her way to college. She grew up in front of us with all the attitude that Monica had as a child—and George and I relished every moment of it.
A teenager sitting on the floor | Source: Pexels
But then, Ellie’s attitude changed. Her feisty personality was no longer cute but rather something that threatened to change everything about her.
That Sunday morning began like any other, with the breeze taking over the kitchen as I did the weekly pancake and bacon breakfast. It was a routine that George and I had established so many years ago, that it was almost second nature now.
Pancakes with bacon and eggs | Source: Pexels
George made us cups of tea—the way he always did—when the doorbell rang, slicing through the calm morning.
I switched off the stove and went to answer.
Tea being poured | Source: Unsplash
There she was, our granddaughter, standing at the threshold, her eyes completely avoiding mine.
“Hi, darling,” I said, stepping aside to let her in. “You’re just in time for breakfast!”
Ellie frowned slightly and nodded to George when he came to see who was at the door.
A red door with a metal doorknob | Source: Unsplash
“Come on, the bacon is extra crispy,” George told her, reaching out to hug her.
But Ellie shook her head.
“Look, I’ll get straight to the point,” she said, her voice trembling slightly, betraying the cold front that she was putting up.
A smiling teenage girl | Source: Unsplash
Everything was odd about her behavior. Usually, she would barge in with hugs and kisses, and would ask us about our health. She would bring us cookies—always made with less sugar. She would make her love known.
But today, Ellie was a shadow of the child that had grown up in front of us.
A tin of cookies | Source: Unsplash
“You remember Tom?” she asked, casually.
Tom was her boyfriend. He was already in college and living off student loans. George and I had met him a few times and he had seemed decent enough. But there was always something about him that seemed off to me.
A smiling young man | Source: Unsplash
“I don’t know what she sees in him, Mon,” I told my daughter one afternoon when we went to a coffee shop to catch up.
“I don’t know either, Mom,” Monica said, digging into a slice of cake. “Eddie isn’t happy about her dating someone older, but you know Ellie. She made her case about it, saying that Tom was good for her. And that he was helping her understand the transition between high school and college.”
A table in a coffee shop | Source: Unsplash
Now, Ellie leaned against the wall and continued to speak.
“Tom’s got this startup idea, right? And it is all about renewable energy or something along those lines. He has been speaking to lots of people—advisors and so on. It could be big. Like huge. But there’s a catch. He needs cash to really get it going.”
People sitting around with plans | Source: Unsplash
I watched as my granddaughter took her phone out of her pocket. She continued to avoid eye contact with us.
George and I exchanged a glance. I had a feeling of what was going to come next.
A person holding a phone | Source: Unsplash
But still, Ellie’s words felt like a punch to the gut, delivered with a coldness that I couldn’t believe. It wasn’t something that I had ever associated with her.
“I need you guys to sell the house and move in with Mom and Dad. You’ll get a lot of money from this house, especially because of the neighborhood. It’s a good thing. And you’re old anyway, don’t you want to be back with Mom?”
A person holding house keys | Source: Pexels
“And then what?” I asked.
“And then you can give the money to Tom for his project!” she exclaimed, throwing her hands in the air.
George’s cup clattered against the saucer, his brow furrowed deeply in pain and disbelief at the disrespect coming from Ellie.
A disappointed old man | Source: Unsplash
“Ellie,” he said. “This is our home. Not some investment to cash out. It is filled with every memory of us, of our family. Why would you ask us to just give it up for a business venture that sounds like a scheme?”
I remained silent. I didn’t want to step in yet. I sat down on the couch, waiting for George to make Ellie see reason.
Ever since she was a little girl, he was the one person to get her to calm down and get back to herself.
An old woman sitting on a chair | Source: Pexels
“Because you’re my grandparents!” Ellie’s voice cracked, her usual composure slipping. “You should want to help me. Tom’s idea will work. You’ll see. We just need this startup capital.”
The room filled with a tense silence, the kind that suffocates.
I could see the desperation in her eyes, a wild, unsettling determination. It was clear that she was lost in her love for Tom, seeing only what she wanted to see.
A close-up of a teenage girl | Source: Unsplash
But I knew in my gut that Tom wasn’t the right person for her. Despite the age difference, there was just something wrong about them.
George and I exchanged a look of shared heartache. We both knew that confronting her directly wouldn’t help—it would only drive her away and try to find the money in a different way.
“We’ll see what we can do,” George told her.
A smiling old man | Source: Unsplash
After she left, we sat down, the weight of her visit pressing down on us. I began to wash the dishes, letting George come up with a plan.
“We need to show her, not tell her, about this man’s true character,” he said, his voice resolute.
George went into an elaborate scam about creating a fake lottery ticket.
“Don’t worry, Mary, Johnny is a wizard on his computer, he can create it for us.”
A person washing dishes | Source: Unsplash
Johnny was our neighbor’s son, and he was always creating posters for missing pets around the neighborhood.
George’s idea was a harmless trick meant to unveil Tom’s intentions without causing permanent scars. We spoke to Johnny, ordering a ticket designed for a jackpot winner and sent it to Tom anonymously—suggesting that it was a lucky draw from a local store.
Man using a laptop | Source: Pexels
The result was more immediate and devastating than we’d anticipated.
Two days later, as I was vacuuming the living room, Ellie returned, her face pale and streaked with tears.
“What happened?” I asked, enveloping her into my arms.
“Tom’s gone,” she said. “Grandpa told me what he did. And as soon as Tom thought that he had won, he packed his bags. He left to start his real life in the Caribbean—without me.”
A crying teenage girl | Source: Pexels
Her voice broke, and my heart with it.
I knew that Tom was going to end in heartbreak, but I didn’t think that it was going to happen so soon.
“I thought he loved me,” she whimpered. “How could I have been so blind?”
I stroked her hair, feeling her shudder with each sob.
A woman comforting a girl | Source: Pexels
“Oh, sweetheart, we didn’t want to hurt you like this,” I murmured, my own eyes damp with sorrow. “We just needed to see if he was the real deal before all of our lives changed to help him.”
As the weeks turned into months, Ellie’s wounds began to heal. She spent more time with us, bringing her art material and setting herself up in the living room.
Eventually, Tom was just another part of her growing up experience.
A person holding their art | Source: Pexels
What would you have done?
If you enjoyed this story, here’s another one for you |
When Eliza’s 10th wedding anniversary comes around, she hopes that Tom will take her away for a romantic getaway. But when he forgets about their anniversary and needs to work, she turns it into a girls’ weekend, only for her to see that Tom’s business trip is a rendezvous with his mistress.
Read the full story here.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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