The two-year-old dog became lethargic, thin and listless, deteriorating to the point that it was admitted to a pet hospital for a week for a blood transfusion.
“I was really worried about him,” Ms Powell, an enrolled nurse, said.
Testing confirmed Leo had ehrlichiosis, a disease transmitted through bites from brown dog ticks carrying the Ehrlichia canis bacteria.
But what worried the specialists is that Leo lives in the urban Top End, which some experts fear is becoming a new stronghold for a disease spreading like wildfire.
The first Australian case was detected in the Kimberley region of Western Australia in May last year.
By June, cases were rapidly emerging in Katherine in the Northern Territory and the surrounding remote communities.
The Northern Territory government has recorded 370 confirmed cases — 110 in the Darwin and Arnhem Land region, 149 in the Katherine region, 36 in Tennant Creek and in Alice Springs and surrounds, 75.
Experts say countless more have been left undetected in remote communities with little intervention.
“When we finally got to bring him home, [the vets] said he needs to stay inside, he’s at risk of spontaneous bleeding and he might not make it,” Ms Powell said.
“It was very full-on, very emotional.
“There were tears basically every night.”
Until the first cases were discovered just last year, stringent biosecurity controls had kept ehrlichiosis out of Australia.
Experts are still baffled by how the disease got in but, according to Professor Peter Irwin from the School of Veterinary Medicine at Murdoch University, the disease is now considered “endemic” across the NT.
“Ehrlichiosis is one of the most serious diseases of dogs in my opinion,” he said.
“It makes them very ill, and many dogs can die.
“Once it establishes into a tick population, it’s very difficult to eradicate.”
Common symptoms include lethargy, fever and cloudy eyes, which can be cleared up with antibiotics but, if left untreated, the disease can lead to blindness, uncontrollable bleeding and death.
“The problem with this disease is that dogs travel and spread infected ticks,” Professor Irwin said.
“Dogs that have moved from an endemic area of the community into the city will possibly bring ticks with them, and the ticks can then drop off.
“There have now been dogs with the disease identified in most other capitals, most as a result of travel from the north.”
Doctor Stephen Cutter, the head veterinarian at Darwin’s Ark Animal Hospital, is no stranger to the crippling disease.
He said up to 40 per cent of the dogs are infected in the remote communities of the Top End he visits on rotation.
But in August of last year, he saw his first case in a pet that had not left urban Darwin.
Arielle Giles, a vet at the Darwin Veterinary Hospital, confirmed the disease’s spread to Darwin, saying she had seen six cases in the past three months.
“It’s a devastatingly bad disease and it’s really difficult to treat,” Dr Cutter said.
“It’s basically everywhere and it’s now a matter of living with it.”
Both Professor Irwin and Dr Cutter said keeping ticks at bay is the best way to prevent ehrlichiosis.
“Because the infection is transmitted so quickly from the tick bites, the most important way of protecting your dog is to use a product, such as a collar that kills ticks before they bite,” Professor Irwin said.
It has now been five months since Leo was struck down by the tiny parasite and, while he is still getting regular check-ups and his future is looking brighter, vets can’t give the all-clear.
“Ehrlichiosis is really nasty in that it can stay hidden in the bone marrow for a long period of time,” Dr Cutter said.
Earlier this year, the NT government brought on a new coordinator to transition the NT’s response to the disease from a biosecurity threat to managing the outbreak.
“This disease is a nationally notifiable disease, which means that suspected cases of E.canis need to be reported, and free testing can be carried out on blood samples from suspected dogs,” said the chief vet at the Department of Industry, Tourism and Trade, Dr Sue Fitzpatrick.
Dogs have nose for COVID-19, studies show. Why aren’t they used for testing?
As the availability of COVID-19 tests dwindle across Canada, another option to detect the virus in the form of a furry friend may be the next best thing.
Multiple studies show that dogs can be more effective, faster and potentially less expensive than the current tests on the market.
The research has grown since 2020, with University of California Santa Barbara professor Tommy Dickey finding the collective research shows trained scent dogs are “as effective and often more effective” than both the rapid antigen tests many people keep in their homes, and even the PCR tests deployed at clinics and hospitals.
But even with studies showing their effectiveness, COVID-19-detecting dogs are deployed only in certain jurisdictions in various countries.
One such place is the Canines for Care program at Vancouver Coastal Health (VCH), which started looking into the possibility of training dogs to detect COVID-19 in early 2021.
Dr. Marthe Charles, division head of medical microbiology and infection prevention and control at VCH, said the idea stemmed from the early reliance on laboratory testing.
“I think there was a will from public health at the time and also from the various levels of government to try to find a way that was fast, accurate and non-invasive to be able to detect and train as many people as possible,” Charles told Global News in an interview.
Three dogs — two Labrador retrievers and an English springer spaniel — were brought in for training. The dogs were exposed to items such as masks that were worn by patients either negative or positive for the virus. This trained the dogs to recognize what is and is not COVID-19.
Charles said the dogs were trained since being puppies to associate the scent of COVID-19 with food and were rewarded each time they correctly detected a positive case of the virus.
“So from early on in their lives, they’ve associated the scent of a case of COVID to a rewarding scent,” she explained.
This reward method is not just used by VCM. It was also used with a group of dogs sourced in early 2021 for a French study, trained at detection using toys — usually tennis balls — as rewards.
Dr. Carla Simon, owner of Hunter’s Heart Scent Detection Canines in Calgary, said this method of training dogs is common. By using rewards, it can help motivate them to find the scent.
“We would pair, let’s say, the sweat samples with COVID, with their reward, and they notice that every time they find their reward, there’s that special smell,” she explained. “We just have to make it rewarding for the dog.”
She added, however, that the dog chooses the reward so trainers can ensure the canines “show up every day and want to do their job.”
Earlier this month, Dickey along with Heather Junqueira of BioScent, Inc. gathered several peer-reviewed studies into a review that was published in the Journal of Osteopathic Medicine. Dickey said the number of peer-reviewed studies over the past few years went from four to 29, incorporating the work of more than 400 scientists from more than 30 countries and 31,000 samples.
The review noted the effectiveness of dogs’ ability to detect COVID-19 comes down to their noses.
“The nose is not like humans,” Simon said. “It’s massively different, orders of magnitude different, and they can detect things without us being able to smell them.”
Humans have about five to six million olfactory receptors in their noses, while dogs have hundreds of millions. One-third of their brain is devoted to the interpretation of smell — something only five per cent of a human’s brain is committed to, according to Dickey’s review.
The study found dogs’ noses may even be able to detect pre-symptomatic COVID-19 cases, or even those who will develop symptoms later.
Dickey told us in an interview that this could help limit or stop the virus from spreading.
“The longer the wait is between your test and your result, that’s a latent period,” he said. “During that time you’re running around spreading COVID and you don’t know it. The dogs with a direct sniff will be done in seconds.”
Many of the studies conducted, including the work at VCH through the Canine for Care program, have shown dogs’ ability to detect the disease correctly with a success rate of more than 90 per cent. Additionally, the studies also showed a high speed at which the dogs could identify cases. In one study in Thailand, researchers reported the dogs had gone through thousands of samples in just a few weeks.
“The dogs take only one to two seconds to detect the virus per sample. Once they detect a patient, they will sit down,” said Chulalongkorn University professor Kaywalee Chatdarong, who led the 2021 project. “This takes only one to two seconds. Within one minute, they can manage to go through 60 samples.”
Even though the research suggested deploying scent-detection dogs could also be less expensive than rapid or PCR tests, Charles cautioned the logistics that go into training the dog is where it becomes “more prohibitive.”
In VCH’s case, training of the dogs included the medical microbiology lab to provide samples for use, working with infection prevention teams and control nurses, and if a dog identifies an area of concern, cleaning services may need to be utilized. And when it comes to rolling out testing using the dogs, enough staffing is needed for mass screening.
Despite this, while Charles says deploying the dogs widely could be difficult due to staffing and training, they are still one of several tools that can be used in COVID-19 detection.
“I think the way to see those dogs from my perspective is really like another tool in the toolbox and trying to prevent further transmission of pathogen of concern,” she said.
Dickey and Junqueira say dogs should have a place in “serious diagnostic methodology” including in helping should the world face a future pandemic.
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