The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
“Stop Equating Thinness With Health and Happiness,” How Lena Dunham Inspires People to Fall in Love With Their Curves and Scars
There are so many things in the world that we may admire or even get inspired by, but there’s one main thing we may want to fall in love with before we start noticing the beauty of other things. It’s our own reflection in the mirror. Among all the numerous recipes for conjuring up self-love within ourselves, psychologists advise us to never compare ourselves to others and stop caring about other people’s opinions. Actress and producer Lena Dunham knows a lot about cultivating love for her own body despite all the criticism she faced, and she happily shares her journey with us all.
Lena Dunham doesn’t accept the term “body positivity,” and here’s why.
Actress and writer Lena Dunham has recently added another string to her bow and collaborated with the brand 11 Honoré to create a plus-size clothing collection. But the very term “plus size” frustrates Lena, and so is the term “body positivity.” In one of her Instagram posts, she explains that she feels more “body tolerant” than “body positive.”
In her interview, Dunham said, “The thing that’s complicated about the body-positive movement is it can be for the privileged few who have a body that looks the way people want to feel positive. We want curvy bodies that look like Kim Kardashian has been up-sized slightly. We want big beautiful butts and big beautiful breasts and no cellulite and faces that look like you could smack them onto thin women.”
Dunham has a very special relationship with her own body.
Dunhams path to self-love started with a decade-long journey with endometriosis. Since she started her own fight against it, she has been candidly sharing how it influenced both her emotional health and her relationship with her own body image. In her Instagram post, she emotionally described how she fluctuated between loving her body and the opposite.
She wrote, “Ya know when you’re home alone, and you realize you’d be happier in a hot lil’ onesie than your ketchup and cat food stained pajamas? And it’s not about a boy or a photo shoot or a weight loss before-and-after, it’s just for the feeling of glee you get from dressing your one and only corporeal form in pleasing fabrics, the unique pleasure of admiring the twists and turns of the body that loves the heck out of you even when you don’t love it.”
Dunham is powerfully addressing all people who come to her page with criticism.
In 2021, Dunham tied the knot with musician Luis Felber. It was such a darling event for her that she wore 3 wedding dresses to marry her love and shared the photos on her Instagram. However, she started getting some “gnarly” comments in her feed from people who commented on her body and appearance. The actress didn’t hesitate for a minute to address them with a powerful message.
She wrote, “One narrative I take issue with, largely because it’s a story I don’t want other women, other people, to get lodged in their heads, is that I should somehow be criticized because my body has changed since I was last on television. […] But lastly, when will we learn to stop equating thinness with health/happiness?”
Dunham’s powerful message can be echoed in the hearts of many.
For all people who have ever hesitated about embracing their body image, Dunham has some simple yet wise advice. She says, “Of course weight loss can be the result of positive change in habits, but guess what? So can weight gain. The pics I’m being compared to are from when I was with an undiagnosed illness. In the last 4 years, I’ve begun my life as someone who aspires toward health and not just achievement.
These changes have allowed me to be the kind of sister/friend/daughter that I want to be and yes — meet my husband (who, by the way, doesn’t recognize me in those old photos because he sees how dimmed my light was). I say this for any other person whose appearance has been changed with time, illness, or circumstance — it’s okay to live in your present body without treating it as transitional. I am, and I’m really enjoying it. Love you all.”
Do you find Lena Dunham’s example inspiring? What do you love the most about your appearance?
Preview photo credit Steve Granitz / WireImage / Getty Images, lenadunham / Instagram
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