Brenda Lee’s name may not be as recognizable as some of the other music stars from the 1960s but when you think of Christmas, you’ll know her song, and start humming her catchy tune, “Rockin’ Around the Christmas Tree.”
When Lee, now 78, first hit the stage, she wasn’t old enough to drive but her powerful vocals steered her “unprecedented international popularity” as the most successful female artist of the 1960s.
Lee, whose voice defied her diminutive stature at only 4 foot 9, became a fan favorite when she was only 12.
Brenda May Tarpley, born in 1944, got her start in the late 1940s, became huge in the 1950s, and over her career–that started before she left elementary school–she topped the charts 55 times, earning the title as the most successful female recording artist of the 1960s.
When Lee was only eight (according to Rolling Stone), her father, a construction worker, was killed at work and little Brenda–who then changed her last name to Lee–became the family’s primary provider.
Taking care of her younger brother, big sister, and mother–a cotton mill worker–was not a duty, but something she wanted to do. She said that she was thrilled when she made her first $20, so she could help her family: “Even at that young age, I saw that helped our life,” Lee said, adding “It put some food on the table. It helped, and I loved it.”
The Atlanta-born chanteuse, called a “pioneer of early rock and roll,” by the Georgia Encyclopedia, achieved “unprecedented international popularity in the 1960s.”
But, an incredibly humble human, Lee credits those who helped her achieve her dreams. When Christianity Today asked what she thinks about being a legend, Lee said “I don’t think of myself that way!” She continued, “I’m just a girl who’s been blessed to be doing what I’m doing, and there’s a lot of people who’ve sweated a lot of tears and put a lot of life’s work into me to be able to have my dream. So, if I’m a legend, then they’re legends, too.”
In 1956, the young girl joined country star Red Foley for a show at the Bell Auditorium near her home in Augusta, and she belted out “Jambalaya,” by Hank Williams.
She was then signed to appear on Foley’s Ozark Jubilee, a country music show, where millions of viewers fell in love with the sassy 12-year-old whose talent was developed well beyond her age.
In the same year, Lee signed with Decca Records, and the next year, she moved to Nashville, Tennessee, and fusing country with rhythm and blues–highlighted by her hiccupping vocals–she recorded early rockabilly classics like “BIGELOW 6-200,” “Little Jonah,” and “Let’s Jump the Broomstick.”
When asked if–when as a young girl–she was nervous performing in front of large crowds, she answered: “No, not really. Nobody ever told me to be nervous. The stage always felt like a hometown to me because I had been in front of people ever since I was 3 years old, singing to people. So it was a very comfortable spot for me.”
In 1957, Lee earned the nickname “Little Miss Dynamite” for her pint-sized powerhouse recording of the song “Dynamite,” and in 1958, fans heard “Rockin’ around the Christmas Tree,” a genre and generation-crossing holiday standard, released when she was only 13.
“I knew it was magical,” she told Rolling Stone.
Over the next couple of years, she charted with hits like “Sweet Nuthin’s,” “All Alone Am I,” and “Fool #1.”
Most of her songs, however, contradicted her experience as a young girl. Her mother didn’t let her date and she graduated high school not understanding the heartbreak of young love.
She was only 16 when she said “Love could be so cruel” in the song “I’m Sorry” and only 16 when she said “I want his lips to kiss me” in the song “I Want to be Wanted,” both back-to-back hits when she was still in school.
And when she turned 18, she met Ronnie Shacklett, whom she’s now been happily married to for 60 years.
Life on the road for Lee as a youngster had its difficulties. She celebrated her 12th birthday in Las Vegas and speaking with the Las Vegas Journal, Lee explained her loneliness.
“Of course, I wasn’t even allowed to walk through a casino, I was so young. So I didn’t even know what a casino looked like. They took me into the kitchen, then into the showroom. And then when my show was over, I was brought back out through the kitchen and back up to my room. Children weren’t allowed … in the casino area.” She continued, “There wasn’t anything to do in Vegas for a kid. The most fun I had was on the stage.”
Speaking on what she missed out on as a child, the award-winning Lee said, “Many times, I yearned to be with my friends rather than be out there on the road.”
Turns out she made new friends on the road, like with the music group that opened for her at a 1962 show in Germany. “I hung out with John,” she says effortlessly, speaking of John Lennon. “He was extremely intelligent, very acerbic with his jokes, just a gentle person. When I found out that they later said they were fans of my music, I was just floored.”
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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