The Durrant family, a six-person unit that is not only attractive but has overcome some incredible odds, is something to behold when seen as a whole.
In 2001, Alison Spooner and Dean Durrant had their first set of twins, who immediately captured everyone’s attention.
The unpredictability of life on this planet is arguably its most amazing feature.
The unexpected can certainly be distressing or even painful at times, but there are also many situations when we’re pleasantly delighted by something we didn’t anticipate to happen.
Dean Durrant and Alison Spooner appear to be a typical couple from the outside, yet it turns out that their genes are very unique. This is demonstrated by the miracle that resulted in not only one pair of identical twins, but two…
Hayleigh and Lauren Durrant, who are black and white twins, proudly cradle their baby sisters Leah and Miya, who, amazingly, are also…Posted on Wednesday, April 8, 2015 by Talking Babies
Hayleigh and Lauren Durrant, twin sisters from Hampshire in England, were born in 2001 with various skin tones. The white twin resembled their mother, while the black twin resembled their father.
When Alison and Dean initially learned they were expecting twins, they thought the children would be like them both. However, Alison’s parents received a surprise after Laura and Hayleigh were born in 2001.
While Laura’s twin sister had largely taken after her father, Laura had inherited her mother’s fair skin, blue eyes, and red hair.
Naturally, Alison and Dean’s relatives and friends were shocked. The phenomenon is extremely unusual, yet it does occasionally occur.
Growing up wasn’t always easy as their parents had to field questions about how this could have happened and comments of disbelief, and then the girls would face questions from their friends at school.
On the twins’ 18th birthday in 2019, Hayleigh, who has dark skin and hair like her dad Dean, stated they weren’t always accepted.
“Some people can be really rude. They’ll say, ‘You’re lying, you aren’t twins – prove it!’ So we’ll reel off the same address or pull our passports out. It’s nice to see the shock on people’s faces.
“When we went to college it was difficult because there were lots of groups of Asian, white and black kids. The black group were trying to integrate me and I was like, ‘This is my white twin sister.’ No one could believe it. People look at us like it’s some kind of miracle. I’m still amazed that we are twins.”
Meanwhile, Lauren, who has her mother’s green eyes and fair hair, said, “People just assume we’re best friends rather than sisters, let alone twins.
“I’m happy with that because she is my best friend.”
There is a 1 in 500 chance that twins born to multiracial parents will have distinct skin tones.
After only seven years, Alison discovered she was expecting twins once more! When Laura and Hayleigh aged 7, their mother gave birth to another set of identical twin sisters, and the family once more made headlines.
This time, when the babies were discovered to be in the breech position, Alison was induced at 37 weeks. Due to breathing issues, the newborns had to be sent to intensive care right away, depriving Alison and Dean of the opportunity to spend quality time with them.
But when parents could finally see their newborns, they understood that they had overcome yet another obstacle. Another set of miraculous biracial twins was born!
In addition to having distinct skin tones, the daughters, Leah and Miya, made their family the only one in the world to have two sets of multiracial twins.The family of records quickly made it to the Guinness World Records.
Even non-identical twins are uncommon, Dr. Sarah Jarvis of the Royal College of General Practitioners told CBS News.
“To have two eggs fertilized and come out different colors less common so to have it happen twice must be one in millions,” she added.
“I’m almost blown away as the rest of them, there’s no easy way to explain it all,” proud dad Dean told CBS News. “I’m still in shock myself even though the first ones were 7 years ago, it’s amazing.”
Their two older sisters, who have been able to help them navigate the difficulties, assist Leah and Miya.
“The younger ones idolise the older ones and are always copying them. It’s like having two Mini-Mes,” said their father.
“They are best friends and close in every way, apart from looking different. It took me some years to understand the science of how they could appear so different,” their mom added.
Leah shared: “Lauren and Hayleigh are my heroes. I like my older sisters. We want to be like them when we are grown-up.”
Despite their physical disparities, the girls remarked that they are similar in many respects and that they are fortunate to have each other.
Hayleigh explained: “We say the same things at the same time and finish each other’s sentences. Sometimes I know exactly what she is thinking.”
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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