In a small Brazilian town, there resides an extraordinary duo of identical twins named Elis and Eloá. Their story serves as a beacon of resilience and the remarkable power of the human spirit. Afflicted with Hutchinson-Gilford Progeria Syndrome, a rare and fatal genetic disorder causing accelerated aging, these twins confront their adversities with remarkable grace and strength, earning admiration from people worldwide.
Understanding Hutchinson-Gilford Progeria syndrome
HGPS stands as an exceptionally rare disorder, impacting roughly 1 in 20 million newborns globally. Marked by rapid aging from early childhood, individuals with progeria often display growth delays, diminished body fat and hair, prematurely aged skin, joint stiffness, and severe cardiovascular issues. Typically, those with HGPS have an average life expectancy of about 14.5 years, though some may extend into their late teens or early twenties. This syndrome gained public attention through the film The Curious Case of Benjamin Button.
The condition is caused by a mutation in the LMNA gene, which produces the lamin A protein responsible for maintaining the structural integrity of the cell nucleus. The mutation results in the production of an abnormal version of the protein, called progerin, which causes cells to become unstable and die prematurely.
Elis and Eloá’s journey
Elis and Eloá swiftly captured attention because of their distinctive medical condition. Despite the physical hurdles imposed by progeria, their contagious smiles and steadfast optimism have emerged as beacons of hope and inspiration. Guilherme and Elismar, the twins’ parents, have dedicated their lives to offering the utmost care for their daughters, striving to ensure they experience as normal a life as feasible within the confines of their condition.
The family’s path has been far from easy. Their daily life is filled with demanding medical routines, including physiotherapy, aimed at addressing joint stiffness and preserving mobility. Despite these challenges, Elis and Eloá approach each day with remarkable bravery and an unparalleled enthusiasm for life, which is truly remarkable.
A global community of support
Elis and Eloá’s narrative has touched hearts worldwide, sparking a surge of solidarity from individuals and groups committed to promoting awareness about progeria and backing research endeavors. The Progeria Research Foundation, a pivotal entity in this realm, has played a vital role in propelling research forward and furnishing assistance to families grappling with the condition.
Through social media platforms, the twins’ journey is shared with a broad audience, fostering a sense of community and solidarity. Their family’s updates, documenting both the highs and lows of their daily lives, provide invaluable insights into the realities of living with progeria, while also spreading a message of hope and perseverance.
Advances in research and hope for the future
In recent years, there have been remarkable advancements in comprehending and addressing progeria. A notable milestone occurred in 2020 when the U.S. Food and Drug Administration (FDA) granted approval for the first progeria treatment: lonafarnib. This medication has demonstrated efficacy in prolonging the lives of children with progeria by mitigating the accumulation of progerin in cells, thereby decelerating the disease’s advancement.
Though a cure remains elusive, ongoing research presents promising prospects. Scientists are delving into gene-editing methodologies, like CRISPR, as potential means to rectify the genetic mutation at its root. For families such as Elis and Eloá’s, these breakthroughs offer a ray of hope for the future.
And in our other article, we recounted the remarkable story of a girl born without a nose, affectionately dubbed “Voldemort,” who refuses to let her differences define her.
My Father Fired Me Because His Biological Son Wanted My Job — Karma Didn’t Let It Slide
After years of being groomed in his stepfather’s construction company, Sheldon is discarded when David, his stepbrother returns. Instead of retaliating, Sheldon walks out gracefully, only to be head-hunted by a rival company. But a few months in, his stepfather calls him, desperate…
You know things sometimes come full circle? Well, that’s been the story of my life.
I’ve been working at my dad’s construction company since I was 15. At first, it was simple tasks like filing and cleaning out his office, and then more responsibility was placed onto my shoulders as I got through school. And this wasn’t because I wanted to, but because I had to.
A teenage boy | Source: Midjourney
My dad, or technically my stepdad, didn’t let anyone skate by for free. He had one rule and he swore by it. If I wanted to live in his house, I had to earn my keep.
“It is what it is, Sheldon. Take it or leave it,” he said.
Obviously, I had no choice but to take it. Where else was I going to go?
He married my mom when I was 10, and from then on, he always said that I was his “responsibility.”
A couple at their wedding | Source: Midjourney
It never felt that way, because when I turned 16, I had to pay rent, which meant that I had to work at his company after school and work at the local ice cream place during weekends.
But it was fine, I didn’t complain once. I figured that it was all part of his version of tough love.
Over time, I worked my way up in the company. When I graduated from high school, my stepdad gave me no choice but to join the company full-time.
A boy at his high school graduation | Source: Midjourney
“Sorry, Sheldon,” he said one evening over dinner. “But there’s no room for you to go to college or whatever. Now that you have the time and capacity, you need to join the company properly.”
“That’s fine with me,” I said, feeling an odd sense of contentment.
To me, it felt like my stepdad wanted me there, and that was a big deal.
So, I started with the dirty jobs. I cleaned up sites, hauled materials until my muscles were defined, and just did whatever needed to be done. I worked hard, wanting to take pride in the company; it was a family legacy after all.
A man working in construction | Source: Midjourney
And by my mid-20s, I was foreman. I thought I had proven myself, not just as an employee, but as his son, too.
Then everything changed. David came back. His biological son.
David hadn’t been around in years. After my dad’s divorce, he sided with his mom and blamed Dad for everything.
A smiling man | Source: Midjourney
“He said some pretty horrible things to Dad,” my mom told me once when I asked why we didn’t see David.
“So, that’s it? It’s like how I don’t see my biological father?” I asked.
“Pretty much, honey,” she said. “But your father was a cruel man, cruel to the bone.”
An angry man with a clenched fist | Source: Midjourney
While David was gone, I stepped in as the son. I did everything, I put in the work, but when David decided to resurface, all of that seemed to vanish.
“I don’t get it,” I said to my mom one night. “David hasn’t spoken to Dad in over a decade. And now he’s back, acting like nothing happened between them?”
My mother sighed and cut a piece of banana bread for me.
A loaf of banana bread | Source: Midjourney
“Your father misses him, honey,” she replied quietly. “He’s just trying to make things right.”
I sighed. I could understand that, but it still didn’t sit well with me.
A few days later, I was called into my dad’s office. He didn’t even look up from his desk. He just cleared his throat.
“We need to let you go, Sheldon,” he said.
A man sitting in his office | Source: Midjourney
“What?” I blinked, trying to process. “You’re firing me? Really, Dad?”
He finally glanced up but refused to make eye contact with me.
“David’s coming on board, and, well, we don’t have room for both of you in management. He’s got the degree, you know? Construction management?”
An older man | Source: Midjourney
“So?” I asked, struggling to keep my voice calm. “I’ve been here for over a decade. I’ve earned this.”
“It’s time I help David get on his feet,” he muttered. “He’s my son, after all. And I lost so many years with him.”
I sat there for a second, stunned.
“I thought I was your son, too.”
“You are, but you’re not blood,” he said.
An upset man | Source: Midjourney
Just like that, it was over. No severance, no handshake, not even a thank you for my years of hard work. I felt the anger building, but I kept my cool.
“All right,” I said, standing up. “Cool. Good luck.”
I walked out not knowing what would happen next.
“Just move in with me,” my girlfriend, Bea, said when I told her what had happened. “You don’t need to see him every day after this. Take some time away.”
A smiling young woman | Source: Midjourney
I listened, and within a few hours, I was out of our home and into her apartment.
Within a week, I landed a new job at a rival construction company. I’d made some solid connections over the years, and they jumped at the chance to hire me.
“It’s for a project manager role, Sheldon,” the owner said. “I know it’s not what you’re used to, but I’ve followed the projects that you’ve overseen. You’re ready for this.”
A smiling man in a suit | Source: Midjourney
I accepted without hesitation. This new role meant more pay, and best of all? More respect.
“You’re going to love it here,” my new boss said when he took me around, showing me my new office. “We take care of our people, Sheldon. None of that cutthroat stuff that I’ve heard your father does. And don’t worry, we cover dental, medical, and everything else.”
I smiled. I could already tell that this was going to be an entirely different experience from what I was used to.
A smiling man | Source: Midjourney
It didn’t take me long to settle into my new job, and I loved every second of it. I had projects that ranged from movie theater construction, to malls, to even theme parks. It was only going to get better from there.
“I miss you at home, darling,” my mother said when we met at a coffee shop for breakfast one weekend.
“I know, Mom,” I said. “I miss you too. But you understand why I had to move, right?”
A woman sitting in a coffee shop | Source: Midjourney
“Of course I do, Sheldon,” she said gently. “And it was time to spread your wings, too. But if I’m being honest with you, there seems to be something big going on with Dad’s company. He’s been very stressed. He and David are not really on speaking terms now. They’re just polite to each other.”
“Trouble in paradise?” I asked sarcastically.
“I think so,” my mother said, buttering a slice of toast.
Toast on a board | Source: Midjourney
It wasn’t long before whispers started to flood our industry, talk of my dad’s company going under seemed to be the biggest news. Apparently, things really weren’t going well since David had taken over.
My stepbrother had been losing clients, mismanaging projects, and making mistake after mistake. Some of the same clients I had built relationships with left my dad’s company and signed with me instead.
Then, one day, I was sitting in my office, flipping through a stack of resumes when I came across David’s.
A stack of paper | Source: Midjourney
“No way,” I muttered, staring at the paper. It was surreal. The same David who replaced me at my dad’s company was now applying for a job at my new one.
I couldn’t resist. I called him in for an interview.
When David walked in, he looked worn, like life had knocked him around. He didn’t even recognize me at first, but when he did, the color drained from his face.
A shocked man | Source: Midjourney
“Have a seat,” I said.
He sat down, clearly uncomfortable. The confidence he once had was gone.
“So,” I began, flipping through his resume. “Why are you looking for a job here?”
He gulped.
“I need something new. Things didn’t work out at my dad’s company.”
A man holding his head | Source: Midjourney
“What happened?” I asked.
“Just… I made some mistakes. I lost us some clients.”
“I see,” I replied, leaning back in my chair. “You do realize that this is the same industry, right? We’re not going to make it easy for you.”
David nodded.
“I’m ready to work,” he said.
“We’ll let you know,” I said.
A man sitting at his desk | Source: Midjourney
As he left, I couldn’t help but feel a mix of satisfaction and pity. Karma had done her job. Still, it felt good to know that I’d landed on my feet while David struggled.
A few weeks later, my phone rang. It was my dad.
“Sheldon, come back,” he said simply. “The company is failing. David walked out after he messed up again. We’re in trouble. I need you to come back. Help me out, maybe take over.”
I let the silence hang in the air for a moment.
An older man using his phone | Source: Midjourney
“I’m sorry, Dad,” I said quietly. “But I’ve moved on. I’m happy where I am.”
He sighed heavily.
“I understand, son. I’m… I’m proud of you, you know?”
“Thanks. I wish you the best,” I said.
“Come over for dinner soon?” he asked hopefully.
A man talking on the phone | Source: Midjourney
“Yeah, maybe,” I said.
When I hung up, I felt a weight lift off my shoulders. Years of trying to prove myself to him were over.
What would you have done?
A smiling man | Source: Midjourney
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